Eric Harley
Harvey Mudd College Mathematics 2004
| Thesis Proposal: | Modeling Cancer Cell Response to Immunotherapy |
|---|---|
| Thesis Advisor: | Prof. Lisette de Pillis |
| Second Reader: | Prof. Jon Jacobsen |
| E-Mail: | eharley@math.hmc.edu |
Modeling Cancer Cell Response to Immunotherapy
Project Statement
The goal of this project is to create a mathematical model and numerical simulation for cell growth and response to three modes of therapy: anti-angiogenesis therapy, immunotherapy, and chemotherapy. We will then validate the model against clinical data to assess the model's success.
Significant work has been done modelling cancer cell growth under the assumptions of spatial homogeneity, but only preliminary simulations exist for spatial heterogeneity. We hope to extend this work by refining the spatially heterogeneous models and observing its response to the three modes of drug therapy.