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Trachette L. Jackson: “Mathematical Models of Tumor Angiogenesis”

Professor Trachette L. Jackson, 2014 Moody Lecture Speaker

Professor Trachette L. Jackson of the University of Michigan presented the eighth lecture in The Michael E. Moody Lecture Series on “Mathematical Models of Tumor Angiogenesis”

Trachette L. Jackson earned her Ph.D. in Applied Mathematics in 1998 from the University of Washington, and is currently a Full Professor of Mathematics at the University of Michigan. Dr. Jackson is an award-winning teacher scholar whose research in mathematical oncology has received international attention. In 2003, she became second African American woman to receive the prestigious Alfred P. Sloan Research Award in Mathematics; in 2005 she received a James S. McDonnell 21st Century Scientist Award; in 2008 Diverse Magazine honored her as one of the year's Emerging Scholars; and in 2010 she received the Blackwell-Tapia Prize. The main focus of Dr. Jackson's research is combining mathematical modeling, numerical simulation and in vivo tumor vascularization experimentation to gain deeper understanding of tumor growth and vascular structure at the molecular, cellular, and tissue levels. Dr. Jackson has built her career on collaborative research and educational activities that cut across traditional disciplinary boundaries, and envisions that this type of research will eventually change the face of cancer research.

More information about Trachette L. Jackson is available from her website.

The lecture took place on Friday, October 10, 2014, at 7:00 PM, in HMC's Shanahan Center Auditorium.

Abstract

Fall 2014 Moody Lecture Poster Download the Poster

Cancer is the collective name given to an entire class of diseases characterized by rapid, uncontrolled cell growth. To ensure continued growth, tumors must acquire a continuous supply of nutrients and the ability to export metabolic waste. They accomplish this by recruiting new blood vessels from the nearby existing vasculature, a process known as tumor-induced angiogenesis. Angiogenesis is a critical bifurcation point in cancer progression as it provides the necessary blood supply for the growth of solid tumors beyond a few millimeters in diameter. The angiogenic cascade is an extremely complex, yet well-ordered series of events involving biochemical and biomechanical signals that operate across several temporal and spatial scales. In this talk, classical and current mathematical models of tumor angiogenesis will be explored and recent advances will be highlighted.