Eric Harley

Harvey Mudd College Mathematics 2004

Thesis Proposal: Modeling Cancer Cell Response to Immunotherapy
Thesis Advisor: Prof. Lisette de Pillis
Second Reader: Prof. Jon Jacobsen

Modeling Cancer Cell Response to Immunotherapy

Project Statement

The goal of this project is to create a mathematical model and numerical simulation for cell growth and response to three modes of therapy: anti-angiogenesis therapy, immunotherapy, and chemotherapy. We will then validate the model against clinical data to assess the model's success.

Significant work has been done modelling cancer cell growth under the assumptions of spatial homogeneity, but only preliminary simulations exist for spatial heterogeneity. We hope to extend this work by refining the spatially heterogeneous models and observing its response to the three modes of drug therapy.