# Ben Fogelson

Harvey Mudd College Mathematics 2009

Final Thesis: | Mathematical Model of the Chronic Lymphocytic Leukemia Microenvironment |
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Thesis Proposal: | Mathematical Modeling of Immune Cancer Interactions |

Thesis Advisor: | Prof. Lisette de Pillis |

Second Reader: | Prof. Rachel Levy |

## Mathematical Model of the Chronic Lymphocytic Leukemia Microenvironment

A mathematical model of the interaction between chronic lymphocytic leukemia (CLL) and CD4+ (helper) T cells was developed to study the role of T cells in cancer survival. In particular, a system of four nonlinear advection - diffusion-reaction partial differential equations were used to simulate spatial effects such as chemical diffusion and chemotaxis on CLL survival and proliferation.