Ben Fogelson

Harvey Mudd College Mathematics 2009

mugshot
Final Thesis: Mathematical Model of the Chronic Lymphocytic Leukemia Microenvironment
Thesis Proposal: Mathematical Modeling of Immune Cancer Interactions
Thesis Advisor: Prof. Lisette de Pillis
Second Reader: Prof. Rachel Levy

Mathematical Model of the Chronic Lymphocytic Leukemia Microenvironment

A mathematical model of the interaction between chronic lymphocytic leukemia (CLL) and CD4+ (helper) T cells was developed to study the role of T cells in cancer survival. In particular, a system of four nonlinear advection - diffusion-reaction partial differential equations were used to simulate spatial effects such as chemical diffusion and chemotaxis on CLL survival and proliferation.